BPC-157

BPC-157 research peptide in Thailand

BPC-157 (Body Protection Compound 157) is a synthetic pentadecapeptide — a 15-amino-acid fragment derived from a protein found in human gastric juice — studied in preclinical models of tendon, ligament, gut, and blood-vessel (angiogenesis) repair. Almost all published BPC-157 evidence comes from rodent and in-vitro experiments, largely from the Sikirić research group; there are no completed controlled human efficacy trials.

This listing is supplied strictly for laboratory research use only. It is not a medicine, supplement, or treatment, and is not for human or veterinary use.

Quick facts

Product

BPC-157 (Body Protection Compound 157)

CAS number

137525-51-0

Molecular weight

~1419.5 g/mol

Intended use

laboratory research use only

How BPC-157 works

In animal and cell studies, BPC-157 is described as a cytoprotective peptide that acts on several repair pathways at once rather than a single receptor. The mechanism most often reported is promotion of angiogenesis — new blood-vessel growth toward injured tissue — through upregulation of VEGF signalling, alongside activation of the FAK–paxillin pathway, which in cultured tendon fibroblasts is associated with faster cell migration and outgrowth.

Researchers also describe interactions with the nitric-oxide (NO) system and with growth-hormone receptor expression in fibroblasts, and, in gastrointestinal models, stabilisation of the mucosal lining against NSAID-induced damage. These are mechanistic observations from preclinical work, not demonstrated outcomes in humans.

Key research findings

• In cultured rat Achilles tendon fibroblasts, BPC-157 promoted tendon-explant outgrowth, cell survival under stress, and cell migration, effects linked to the FAK–paxillin pathway (Chang et al., J Appl Physiol, 2011).
• In Wistar rats subjected to massive small-bowel resection, BPC-157 was reported to reduce gastrointestinal, liver, and brain lesions and to counter failed anastomosis healing (Vukojević et al., PLoS One, 2016).
• A 2019 review concluded that BPC-157 showed consistently positive soft-tissue healing signals across studies, while stressing that the majority were small-rodent models and that efficacy remains unconfirmed in humans (Gwyer et al., Cell Tissue Res, 2019).

Research applications

• Tendon and ligament healing models, including Achilles tendon and transection studies
• Gastrointestinal research: gastric ulcer, NSAID-induced mucosal injury, and intestinal anastomosis models
• Angiogenesis and wound-healing assays examining VEGF-driven vessel growth
• Muscle injury and connective-tissue repair models
• Cytoprotection and organ-protection studies across multiple tissues
• In-vitro fibroblast migration and collagen-signalling work

Dosing in the literature

The published rodent work expressed doses on a body-weight basis rather than as fixed amounts — most often ~10 µg/kg, with a much lower ~10 ng/kg arm in several of the Sikirić experiments — and gut-focused models frequently used the oral route rather than injection. These figures summarise how doses were expressed in the published animal literature and are provided for reference and product identification only — not as administration guidance. To convert a target concentration into working volumes for research use, see the BPC-157 peptide calculator.

Reconstitution & storage

Solvent

Bacteriostatic water — most common in laboratory practice

Mixing

Add solvent slowly against the vial wall and swirl gently until dissolved; do not shake

Storage

Refrigerate at 2–8 °C after reconstitution

Use within

About 4 weeks of reconstitution, in common lab practice

Freeze / light

Keep lyophilised powder frozen for long-term storage and protect from direct light

BPC-157 ships as a lyophilised powder and is reconstituted with bacteriostatic water using standard sterile handling. In Thailand's heat and humidity, minimise time at room temperature and store promptly.

Selected research

• The promoting effect of pentadecapeptide BPC 157 on tendon healing involves tendon outgrowth, cell survival, and cell migration — J Appl Physiol, 2011
• Effects of Diclofenac, L-NAME, L-Arginine, and Pentadecapeptide BPC 157 ... in 24 Hour-Short-Bowel Rats — PLoS One, 2016
• Gastric pentadecapeptide body protection compound BPC 157 and its role in accelerating musculoskeletal soft tissue healing — Cell Tissue Res, 2019
• A new gastric juice peptide, BPC: an overview of the stomach-stress-organoprotection hypothesis — J Physiol Paris, 1993
• Pharmacokinetics, distribution, metabolism, and excretion of body-protective compound 157 in rats and dogs — Frontiers in Pharmacology, 2022 (reported elimination half-life under 30 minutes after IV/IM administration; no human half-life established).
• Browse all BPC-157 studies on PubMed

Related compounds

• TB-500 — a synthetic Thymosin Beta-4 fragment studied in overlapping tissue-repair models; frequently referenced alongside BPC-157 in the literature, though the two act through different mechanisms.
• Bacteriostatic water — the solvent most commonly used to reconstitute lyophilised research peptides such as BPC-157.

For a side-by-side comparison, see BPC-157 vs TB-500 and browse more tissue-repair signalling compounds.

BPC-157 FAQ

Compliance note

BPC-157 is presented here for research identification and laboratory handling reference only. It is not for human or veterinary use and is not intended to diagnose, treat, cure, or prevent any disease.