TB-500

TB-500 research peptide in Thailand

TB-500 is a synthetic peptide corresponding to the active region of Thymosin Beta-4 (Tβ4), studied in preclinical models of tissue repair, cell migration, angiogenesis, and cardiac and corneal healing. It is best known in the literature for its actin-regulating activity, and it is frequently examined alongside BPC-157 in recovery-focused research.

This listing is for laboratory research use only. The evidence base for TB-500 is largely preclinical (cell and animal models); it is not a medicine, supplement, or recovery product.

Quick facts

Product

TB-500 (synthetic Thymosin Beta-4 fragment)

Related protein

Thymosin Beta-4 (Tβ4), a 43-amino-acid peptide, ~4.9 kDa

Note

TB-500 is a fragment, not full-length native Tβ4; the two differ in size and identity

Intended use

laboratory research use only

How TB-500 works

Thymosin Beta-4 is one of the most abundant actin-sequestering peptides in mammalian cells. It binds free G-actin monomers, buffering the pool of actin available for polymerisation and allowing cells to reorganise their cytoskeleton and migrate toward sites of injury. TB-500 reproduces the short active region responsible for much of this behaviour, which is why researchers use it as a lower-molecular-weight stand-in for the full protein in migration and repair models.

Beyond actin regulation, the published literature links Tβ4 to endothelial cell migration and new blood-vessel formation (angiogenesis), to survival signalling in cardiac cells, and to reduced inflammatory signalling at wound sites. These are findings from specific preclinical studies, not outcomes attributed to this product.

Key research findings

• In a mouse myocardial-infarction model, Thymosin Beta-4 activated integrin-linked kinase and Akt signalling, promoted cardiac cell migration and survival, and improved cardiac function after coronary ligation (Bock-Marquette, Nature, 2004).
• In a rat full-thickness wound model, Tβ4 increased re-epithelialisation by up to 61% versus saline controls and stimulated keratinocyte migration, collagen deposition, and angiogenesis (Malinda, J Invest Dermatol, 1999).
• In a mouse alkali-burn model, topical Tβ4 accelerated corneal re-epithelialisation and reduced inflammatory cell infiltration and inflammatory-cytokine expression (Sosne, Exp Eye Res, 2002).

Research applications

• Soft-tissue, tendon, and ligament repair models
• Cardiac repair and post-ischaemic cardiomyocyte survival studies
• Dermal wound-healing and re-epithelialisation research
• Corneal wound-healing and ocular anti-inflammatory models
• Angiogenesis and endothelial cell migration assays
• Comparative repair-pathway studies alongside BPC-157

Dosing in the literature

That range is drawn from the larger-animal work rather than from human trials. This is a summary of parameters as reported in research references, not administration guidance. To model concentrations for a defined protocol, use the TB-500 peptide calculator.

Reconstitution & storage

Solvent

Bacteriostatic water — standard for lyophilised research peptides

Mixing

Add solvent down the vial wall and swirl gently until dissolved; do not shake

Storage

Refrigerated (2–8 °C) after reconstitution, in common laboratory practice

Use within

A few weeks once reconstituted

Freeze / light

Keep lyophilised powder frozen or cold, sealed, and protected from light

Reconstitute with bacteriostatic water using sterile technique. In Thailand's heat and humidity, protect vials from ambient temperature swings during storage and courier handling.

Selected research

• Thymosin beta4 activates integrin-linked kinase and promotes cardiac cell migration, survival and cardiac repair — Nature, 2004
• Thymosin beta4 accelerates wound healing — J Invest Dermatol, 1999
• Thymosin beta 4 promotes corneal wound healing and decreases inflammation in vivo following alkali injury — Exp Eye Res, 2002
• Thymosin β4: a multi-functional regenerative peptide. Basic properties and clinical applications — Expert Opin Biol Ther, 2012 (review)
• Browse all indexed Thymosin Beta-4 literature on PubMed

Related compounds

• BPC-157 — a pentadecapeptide studied for tendon, gut, and tissue repair; frequently discussed together with TB-500 in recovery research because the two are studied through distinct (local vs systemic) repair mechanisms.
• Bacteriostatic water — the standard diluent used to reconstitute lyophilised research peptides.

For a side-by-side comparison, see BPC-157 vs TB-500. See also: more tissue-repair signalling compounds.

TB-500 FAQ

Compliance note

TB-500 is supplied for laboratory research use only. It is not for human or veterinary use, and it is not intended to diagnose, treat, cure, or prevent any disease. All findings referenced above are the results of specific published studies, not claims about this product.